Here, by directly imaging the lung microcirculation in mice 8, we show that a large number of megakaryocytes circulate through the lungs, where they dynamically release platelets. The bone marrow has been proposed to be a major site of platelet production, although there is indirect evidence that the lungs might also contribute to platelet biogenesis 4, 5, 6, 7. Platelets are critical for haemostasis, thrombosis, and inflammatory responses 1, 2, but the events that lead to mature platelet production remain incompletely understood 3.
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